Her first breakthrough came in 1989 when Kalyanji Anandji chose her to sing "Tirchi Topi Wale" for the movie Tridev.

She worked with music directors such as Nadeem-Shravan, Raamlaxman, Jatin–Lalit, Anand–Milind, Viju Shah, Bappi Lahiri, Laxmikant–Pyarelal, Channi Singh, Rajesh Roshan, Anu Malik, A. R. Rahman and singers like Kishore Kumar, Amit Kumar, Kumar Sanu, SP Balasubramanyam, Udit Narayan, Abhijeet, Mohammed Aziz, Vinod Rathod, Sudesh Bhosle, Sonu Nigam, Babul Supriyo, Lucky Ali, Alka Yagnik, Kavita Krishnamurthy, Sadhana Sargam.

In 2006, she came out with an album entitled "Mere Piya", which included several solo performances by herself as well as a duet together with popular singer Sonu Nigam.

[2] Sapna Mukherjee has done staging live concerts in US, Canada and the UK.

[3] She sang for Bollywood leading actresses: Rekha, Dimple Kapadia, Sridevi, Madhuri Dixit, Juhi Chawla, Karisma Kapoor, Raveena Tandon, Sonali Bendre, Sushmita Sen among others.