Sara Pérez Romero was born on June 19, 1870, in San Juan del Río, Querétaro.

However, when Madero was transferred to San Luis Potosí, she was forced to rent a house near the penitentiary because they did not let her be with her husband.

Pérez Romero saw him whenever she could; also, together with the potosino Pedro Antonio de los Santos, she raised a bail of ten thousand pesos so Madero could go free.

Being the first lady, Pérez Romero rallied the troops, organized proselytizing acts, held festivals in favor of the victims of the armed movement, assisted at workers' meetings, and received the organizers of women's political clubs (such as the Hijas de Cuauhtemoc), and attended committees.

[4] Pérez Romero and her husband were the bridesmaid and best man for the wedding of Emiliano Zapata and Josefa Espejo in 1911.

Upon the death of her husband, Pérez Romero was exiled to Cuba, where she was taken in by the ambassador Manuel Márquez Sterling.

In 1916, three years after the Ten Tragic Days, the American journalist Robert Hammond Murray interviewed Sara Pérez Romero.

Also present were the former presidents Pascual Ortiz Rubio, Roque González Garza, and the incumbent at the time, Miguel Alemán Valdés.