[6] When she was 16, she became pregnant, and had an abortion on her 17th birthday, an experience detailed in her memoir, Animal: The Autobiography of a Female Body.

[8] Pascoe has appeared in many television programmes and panel shows, including Stand Up for the Week, The Thick of It, Mock the Week, The Increasingly Poor Decisions of Todd Margaret, Campus, Being Human, Twenty Twelve, QI, Have I Got News For You, Would I Lie to You, Hypothetical, and W1A as well as all-female sketch show Girl Friday (part of Channel 4's Comedy Showcase), which she co-wrote.

[15] In 2014, she performed at the Edinburgh Festival Fringe and toured the UK for the first time with the show Sara Pascoe Vs History.

[17] In October 2014, she appeared in Never Mind the Buzzcocks and stood in line at the identity parade round as a former dancer and back-up singer for the entertainer (and Robbie Williams's father) Pete Conway.

[18][19] Also that month, she appeared on the topical panel quiz Have I Got News for You as a panellist and in one of the sketches of the Channel 4 charity night Stand Up to Cancer.

[20] In 2016, along with numerous other celebrities, Pascoe toured the UK to support Jeremy Corbyn's bid to become prime minister.

[24] She also hosts a related podcast of the same name, in which she interviews people who have experience around sex work, stripping and porn.

She participated in series 3 of the comedy challenge show, Taskmaster, which was broadcast on Dave in October and November 2016.

However, the Covid-19 pandemic caused the project to be delayed, and both series were filmed at the National Gallery in London in summer 2021.

[28] In April 2019, a live recording of Pascoe's LadsLadsLads tour at the London Palladium was shown on BBC Two.

[31] Exploring "heartbreak, family and how to survive them", the series is loosely based on her own life, with Pascoe playing a version of herself.

Pascoe was one of the four competitors on a Christmas edition of The Great British Sewing Bee broadcast on Boxing Day 2020 on BBC 1.