From 1993 to 1994, she appeared in her first regular role in both the sixth and seventh series of the ITV firefighting drama London's Burning, playing Sally Reid, the watch's first female driver.
[3] In 2007, she joined the main cast of the BBC police procedural drama HolbyBlue (2007–2008), playing senior crown prosecutor Rachel Barker throughout the first and second series.
[6] From 2016 to 2018, Powell appeared as psychologist Cass in both series of the Channel 4 sitcom Damned (2016–2018), starring comedians Jo Brand, Alan Davies and Kevin Eldon.
[4] Her other classical credits include playing Cariola in John Webster's revenge tragedy The Duchess of Malfi (2000–2001) for the Royal Shakespeare Company's touring production, directed by Gale Edwards.
"[20] In 2019, she got a small part in the romantic comedy film Last Christmas, written by Emma Thompson and starring Game of Thrones actress Emilia Clarke.
[22] It was broadcast in cinemas worldwide as part of the National Theatre Live programme,[23] just like Powell's other theatrical production, The Madness of George III (2018), with Mark Gatiss as the lead.