Her performance as Rita, a blind teenager brought up in the suburbs of Palermo, earned her several awards, including the Globo D'oro (Italian Golden Globe) for best actress and the "Guglielmo Biraghi" Nastro d'Argento as best new talent.

In 2014, director Liliana Cavani chose Serraiocco for the role of Saint Clare of Assisi in the miniseries Francesco.

That same year, she was cast as Baldwin in the TV series Counterpart, where she acted alongside Academy Award winner J. K. Simmons.

[5] That year, she also played the female lead role in Il signore delle formiche (The Lord of the Ants, directed by Gianni Amelio, which was selected for the Venice Film Festival 79 in Official Competition.

She also took on the role of Giulia in Siccità (Dry, directed by Paolo Virzì), which was selected for the Venice Film Festival 79, Out of Competition, and earned her the prestigious “ Premio Pasinetti" award for Best Ensemble Cast.

Also in 2023, she joined the cast of the French TV series, “Becoming Karl Lagerfeld”, directed by Jérôme Salle which premiered worldwide at Canneseries 2024.

Serraiocco then starred as the female lead in Giorgia Farina’s Ho visto un re, which has been selected for the 2025 Torino Film Festival.