Waisglass first rose to notability as a child actress, playing the role of Jordy Cooper in the children's sitcom Overruled!

As an adult, she starred as Robyn in the 2017 film Mary Goes Round and as Maxine Baker in the Netflix drama series Ginny & Georgia in 2021 and 2022.

[7] In 2008, Waisglass was cast in her first film role in the Gilles Bourdos-directed psychological thriller Afterwards, alongside John Malkovich and Evangeline Lilly.

In 2015, Waisglass was cast in the Anton Corbijn-directed biographical drama film Life,[11] alongside Robert Pattinson and Sir Ben Kingsley.

[3] In 2021, Waisglass starred as Maxine in the Netflix comedy series Ginny and Georgia,[4][16] in a cast that included Brianne Howey, Antonia Gentry, Chelsea Clark and Katie Douglas.