Currently based in Portland, Oregon, she has collaborated with artists and writers like Andy Weir over the course of her career, and has been recently noted for her public opposition to the rise of text-to-image models and generative AI illustrations.

"[1] While a student at the Maryland Institute College of Art (MICA), she started drawing and uploading Sarah's Scribbles on Tumblr in 2013; after graduating in 2014, she worked on the webcomic full-time.

[5] They would go on to publish the follow-up Big Mushy Happy Lump the following year, as well as the subsequent volumes Herding Cats, Oddball, and Adulthood Is a Gift!

On December 31, 2022, she authored a guest essay in the New York Times about the rise of artificial graphist systems such as Stable Diffusion, pointing out threats it presents on graphic creators such as increased confusion, appropriation, reputational impact, and income reduction.

[19] Published editions of Sarah's Scribbles won Andersen the Goodreads Choice Award in Best Graphic Novels & Comics three years in a row.