[3] The onset of the Nigerian Civil War led the family to move back to the United Kingdom when Ferguson was a toddler.

In 1992, Australian journalist and the ABC's London correspondent, Tony Jones, hired Ferguson to help him on a story about French politics.

Ferguson interviewed Australian Labor Party decision-makers and strategists who had engaged in internal conflict that brought down a government which had successfully countered the 2007–2008 financial crisis.

Ferguson interviewed the families of Tori Johnson and Katrina Dawson and the surviving hostages and examined how authorities had failed to comprehend the risk posed by hostage-taker Man Haron Monis.

[19][20] In June 2018, Ferguson presented and produced "Trump/Russia", a Four Corners three-part series on President Donald Trump and his connections to Russia.

[21] In November 2018, Ferguson reported and presented "Bitter End" about conflict within the ABC which led to the resignations of its managing director Michelle Guthrie and chair Justin Milne within one week.

[25] In 2018, Ferguson started working on Revelation, a three-part documentary series for the ABC about the Catholic Church sexual abuse cases in Australia.

[27] Ferguson interviewed convicted Catholic priest Father Vincent Ryan and Bernard McGrath, a former religious brother from the Order of St John of God.

Her interview with Ryan was the first time anywhere in the world a still serving Catholic priest publicly discussed their sexual abuse of children.

[30] Following Revelation, Ferguson stepped down as presenter of Four Corners and accepted the role of China bureau chief for the ABC.

[32][33] It investigated how the Rupert Murdoch-owned American cable network Fox News allegedly became a propaganda vehicle for Donald Trump and helped destabilise America.

[34][35] The Murdoch-owned newspaper The Australian published 45 articles in two days attacking the program, accusing the ABC of doing a "full frontal hit-job on Rupert Murdoch, NewsCorp and the US Fox News Channel".

[38] Ferguson responded to the threat of legal action by Fox News, stating that "We're not in fear of anything ... there are fewer more important stories to look at in America right now.

[44][45] The Australian Communications and Media Authority finalised a year-long investigation on 19 December 2022 which was prompted by various complaints about the story by Fox News.

[46] The ACMA found that the ABC failed to include information about two Fox News presenters (Sean Hannity and Jeanine Pirro) being censured after appearing at a Donald Trump rally and also neglected to report on the role social media played prior to the Capitol riots.

[48] The organisation described Ferguson's story as a "world class report" and "a strong and measured piece of public interest journalism".

[49] Ferguson accused the ACMA of creating the impression that her story was misleading and dishonest when in fact that regulator had found only three minor subjective breaches and had dismissed 19 complaints.

[49] Ferguson's report was also defended by the ABC's director of news, analysis and investigations Justin Stevens who also criticised the ACMA's findings.