[2] Glendening participated in multiple productions during her time at Carnegie Mellon including Wild Party[3] with classmate Megan Hilty, Me and My Girl, Hello, Dolly!, and The Music Man (which was featured in the film Pittsburgh).
In 2005, Glendening made her Broadway debut in Good Vibrations, as part of the Ensemble and as understudy for the role of "Caroline", alongside future-husband Brandon Wardell who played the lead "Dave".
From April 13 to May 23, 2010, Glendening appeared on stage as "Molly" in the world premiere of Nightmare Alley, adapted from the William Lindsay Gresham's book of the same name, at Geffen Playhouse in Los Angeles.
From October 29 to November 4, 2010, Glendening participated in the stage workshop production of Loveless, Texas with Boomerang Theatre Company at Peter Jay Sharp Theater in New York City.
In the fall of 2012, Glendening and husband Brandon served as production managers[6] on Delusion: The Blood Rite, an interactive haunted play in Los Angeles, created by Hollywood stuntman Jon Braver and produced by Neil Patrick Harris.
Glendening has also participated in Neil Patrick Harris's interactive theater experience Accomplice: The Show in Los Angeles and New York City, which describes itself as "Part Game.
Following the cancellation of As the World Turns, it was announced in October that she would replace Brittany Allen in her role of Marissa Tasker, ex-wife of JR Chandler and long-lost twin sister of deceased Babe Carey.
In May 2011, Glendening was cast to star as "nerdy" girl Mandi in the feature-length film Angry Video Game Nerd: The Movie, based on the popular cult web series, and character, of the same name.
In 2012, Glendening starred opposite Eric Roberts in the satirical short Heal Thyself, which premiered at The Hollywood Film Festival and was used as a conversation piece during a healthcare forum at UCLA's Labor Center.