Sasebo Station (佐世保駅, Sasebo-eki) is the major railway station in the city of Sasebo, Nagasaki Prefecture, in Japan.

The Sasebo Line of the Kyushu Railway Company and the Nishi-Kyūshū Line of the Matsuura Railway provide local and regional service and connections to the extensive JR network.

The plaza in front of Sasebo Station contains a multi-level shopping complex called Friesta Sasebo, with coffee shops, clothing, housewares, music and a supermarket.

Within the station itself are souvenir shops featuring local foods and products.

The Matsuura station is above ground level with 1 platform and 2 tracks.