It operates campuses in Moose Jaw, Prince Albert, Regina and Saskatoon; and provides a number of courses and programs through distance education.

The Moose Jaw Campus started off as the Saskatchewan Technical Institute in 1959.

Regina began as the Saskatchewan Institute of Applied Arts and Sciences in 1972.

On January 1, 1988, The Institute Act and the Regional Colleges Act amalgamated Saskatchewan's technical institutes, urban community colleges and the Advanced Technology Training Centre to form the Saskatchewan Institute of Applied Science and Technology (SIAST).

[7][8] Saskatchewan Polytechnic joined Project Hero, a scholarship program cofounded by General (Ret'd) Rick Hillier, for the families of fallen Canadian Forces members.