The Sassafras River is a tributary of the Chesapeake Bay on the Delmarva Peninsula in the United States.

They range from historical and recreational parks to natural resource management areas and wildlife preserves.

The Sassafras River is home to many boats and four large marinas, all of which are located near Georgetown, Maryland (map).

The deepest portion of the Sassafras is just about in the middle of the river, east of buoy 5 on the tip of Ordinary Point.

There are many small bow-riders, cruisers, sailboats of all kinds, and occasionally, one may spot a large motor yacht.