Between 28 and 31 January 1918 the Sassari was again in the first line during the first Italian offensive operations after the Army had spent the second half of 1917 in a defensive posture.

The Italian writer Emilio Lussu had served in the brigade during World War I and would later write an anti-war book about his experiences: A Year on the High Plateau ("Un anno sull'altipiano").

[7][8][1][2][3] The division remained in Istria on garrison duty until 6 April 1941 when Axis forces began the invasion of Yugoslavia.

The heaviest fighting occurred during July 1942 when the division tried to clear partisan forces out of the Velebit mountains.

[3] In March 1943, after the Battle of the Neretva, the division transferred to Rome to aid in the defense of the city in case of an Allied attack.

The future Italian president Sandro Pertini brought a detachment of socialist resistance fighters to Porta San Paolo and around 12:30 the Catholic Communist movement arrived with further reinforcements including famed actor Carlo Ninchi.

However the Italian soldiers handed thousands of weapons over to the civilian population, which was quick to form an organized resistance movement in the city of Rome.

Besides the Sassari the following units were based on Sardinia: After the end of the Cold War the Italian Army disbanded a large number of mechanized brigades in Northern Italy, the equipment of the disbanded units was used to mechanize the Sassari brigade with VCC-2 armored personnel carriers.

[11][3] The Brigade has been deployed repeatedly in out of area operations and has served in Kosovo, Bosnia, Lebanon, Afghanistan and in Iraq, where it lost seven soldiers in various engagements with Iraqi insurgents.