[6] Satartia is a Choctaw word meaning "pumpkin place",[7] likely due to the small gourds that grow in the area.

In the early 1800s, Satartia was a busy shipping point from which cotton was transported by steamboat to New Orleans along the Yazoo River.

[6] During the Civil War, General Grant sailed a gunboat from Vicksburg and captured the village; the Wilson House on Plum Street was used as his headquarters during the occupation.

[6] The war also produced the "Satartia Rifles", of the 12th Mississippi Infantry Regiment, a well-regarded Confederate company and recruitment group.

[8] In February 2020, a pressurized pipeline owned by Denbury Resources carrying liquid carbon dioxide and hydrogen sulfide ruptured "less than half a mile" from Satartia.

[9] In 2022, the Pipeline and Hazardous Materials Safety Administration recommended a civil penalty of $3,866,734 against Denbury Resources.