In 2006, Ishihara made her first starring role in a Fuji TV commercial drama series, Ns' Aoi.

[3] In August 2008, Ishihara made her second stage appearance as Okita Souji in Bakumatsu Junjoden, written and directed by Tsutomu Kohei.

[4] By one month later, in September of the same year, she also portrayed as a Japanese leading JAL flight attendant character Yukari Hayase in Flying Rabbits, directed by Takahisa Zeze.

[6] In 2014, Ishihara is known to Japanese television drama audiences for her portrayal as Saeko Takahashi in Shitsuren Chocolatier[7] and gained popularity by appearing in it.

In the beginning of the Reiwa period in early 2019, Ishihara was appointed as one of the 2020 Tokyo Summer Olympics torch relay ambassadors,[8] which the country had an upcoming game event a year later.