Upon ignoring Crazy Eight's heckling, Funnyface formulated a plan to take hostages from Midville High School in order to draw out Spider-Girl.
Sabreclaw and Mr. Abnormal abducted the students Jack Jameson and Courtney Duran while Raptor flew into the Daily Bugle so that they can alert Spider-Girl of the Savage Six's challenge to her.
Although Spider-Girl defeated Raptor, she learned that she would be forced to fight the other members of the Savage Six in a series of predetermined locations before she could save Jack Jameson and Courtney Duran.
[4] Agent Venom continues to look for Betty and ends up killing Death Adder I after torturing the Human Fly I by ripping his wings off so that he can learn where the Crime Master III is located.
[5] When Agent Venom arrives at the Crime Master III's hideout, he defeats Megatak and severely burns Toxin II.
"[6] In a prelude to the "Hunted" storyline, Kraven the Hunter had Taskmaster and the Black Ant apprehend King Cobra, Rhino, Scorpion, Stegron the Dinosaur Man, Tarantula, and Vulture where Arcade publicly branded them the next Savage Six.
[12] When Kraven the Hunter gives orders to Arcade to deactivate the force field surrounding Central Park, the Savage Six are among the animal-themed characters to get out.
[13] After the Great Hunt is over, Vulture tells King Cobra, Rhino, Scorpion, Stegron, and Tarantula that the Savage Six name has a good ring to it.
[14] More recently, the Savage Six began hounding an action film project directed by a disguised Mysterio under the cooperation of Mary Jane Watson, an actress at the set, only to accidentally turn it into a smashing success.
[15] During the "Sinister War" storyline, the Savage Six crash the world premiere of the movie that Mary Jane and a disguised Mysterio made.