She is known for portraying Amelia Robbins in the Fox series Touch and Kendra Bowen in the 2015 remake of Poltergeist.

[4] Her first significant role was in the 2012 TV movie Rogue opposite Angela Bassett directed by Brett Ratner.

[6] Sharbino stated that she learned a lot from director and star Clark Gregg, and the relationship that Macy and his wife Felicity Huffman had inspired her to take a more proactive role in Hollywood.

[6] Sharbino stated that she took the role of a young starlet who is manipulated by her father and sexually abused by a talent agent because she was drawn to the depth of the character.

[3] Sharbino played high school student Sarah Pearson in American Vandal, which was released in 2017.