In 2015, she released her debut single "Mikazuki", the ending theme of Rampo Kitan: Game of Laplace, and she later sang theme songs for the anime series Erased, Scum's Wish, Fate/Extra Last Encore, Golden Kamuy, My Hero Academia, Sing "Yesterday" for Me, Edens Zero, and Lycoris Recoil.

[2][3] Inspired by the idol boy band Kanjani Eight, Sayuri took up guitar as a hobby and began composing music during her second year of middle school.

[2] In 2012, Sayuri won the Grand Prix at the 5th Music Revolution [ja] finals, where she was their youngest contestant.

[7] In March 2015, Sayuri held her first solo concert, "Yoake no Shitaku", at Tsutaya O-East in Tokyo.

[8] On August 26, 2015, she released her first single "Mikazuki", making her major debut at 19; the song was also the ending theme for the anime series Rampo Kitan: Game of Laplace.

[9] She sang "Sore wa Chiisana Hikari no Youna", the ending theme of the Erased anime; composed and written by Yuki Kajiura, it was released as her second single on February 24, 2016.

[10] On April 23, 2016, she held a solo concert "Mikazuki no Koukai" at the Shibuya WWW; tickets were sold out only seconds after they went on sale.

[19][20] On November 24, 2017, Sayuri's solo concert at Tokyo Dome City Hall became her largest up to this point.

[22] She performed at Anisong World Matsuri at Anime Expo on July 6, 2018, in Los Angeles, California.

[31] Milan Records released an eponymous "World Edition" EP on digital platforms on November 29, serving as Sayuri's international debut.

[38] She released the song "Kamisama" on March 5, 2021; it was used as the opening theme for the drama series Tokyo Kaiki Zake [ja].