Sunni and Isma'ili Shia tradition place Zaynab's tomb in the mosque of the same name in Cairo, Egypt.

[3] The shrine has been managed by Mourtada's family (Arabic: آلُ مُرْتَضَى, romanized: Āl Murtaḍā) since the fourteenth century.

[4] Given their financial investment, the ideological direction of the shrine and the prayer hall follow Ayatollah Khamanei.

Many Shia and pro-government families were driven out of their homes in southern Damascus and sought refuge in al-Sitt.

On 27 July 2023, a motorcycle detonated near a taxi at Kou Sudan Street near Sayyida Zaynab's Shrine, killing at-least six people and injuring another 23.

[11] To maintain security, the Lebanese militant group Hezbollah guarded the site until they were withdrawn before the fall of Damascus in December 2024.