It is run by the York and Scarborough Teaching Hospitals NHS Foundation Trust.

In the early 1930s it was decided to build a new general hospital for Scarborough; the cost of construction of £135,000 was financed in part by the sale of the site of a former hospital at Spring Hill and in part by public subscription.

[3] After the hospital joined the National Health Service in 1948, a major new extension followed in 1988.

[6] A new two-storey urgent and emergency care centre, to cost £47 million, was started in 2022 and should open in 2024.

[7] Annually, the hospital sees an average of 127,000 patient attendances to its emergency department, in addition to 119,000 inpatients and 390,000 outpatient appointments.