The film stars Anna Faris and Regina Hall reprising their roles as Cindy Campbell and Brenda Meeks, respectively.

New cast members include Charlie Sheen, Simon Rex, Anthony Anderson, Kevin Hart, and Leslie Nielsen.

The characters of Ray Wilkins and Shorty Meeks, previously played by Shawn and Marlon Wayans respectively, do not appear, nor are they referenced.

With support from his friends Mahalik and CJ, George beats Fat Joe, but is thrown out after unintentionally wearing a pointy white hood and waves to the largely African American crowd.

Cindy finds the tape in Brenda's room, watches it, and receives a phone call warning her of her death in seven days.

Meanwhile, the Logans encounter an alien disguised as Michael Jackson, and U.S. president Baxter Harris personally visits the farm to investigate the crop circles.

When Cindy asks about how this relates to the aliens, the Architect speculates that Tabitha is summoning them to aid her in destroying humanity.

Returning home, Cindy discovers Cody is missing, the news has been broadcasting the cursed tape for hours, and there have been various sightings of aliens around the world.

Tom sends Cindy, Sue, and Cody into the basement for safety, as he, George and Mahalik go outside to fight the aliens with help from President Harris and the Secret Service.

The aliens reveal they are friendly and have come to stop Tabitha after accidentally watching the tape on a broadcast they intercepted, also mistaking it for Pootie Tang.

Tabitha falsely claims her curse is broken but as she attacks, President Harris opens the door and unintentionally knocks her into the well.

The movie was shot in British Columbia and in Washington, D.C.[7] The score for the film was composed by James L. Venable.

The original soundtrack was released on October 24, 2003, and features hip hop artists such as Buku Wise, Delinquent Habits, Dame Lee, Kebyar, and others.

In the alternate ending, Cindy is told Cody does not exist by her psychiatrist (played by William Forsythe).

One of the scenes that appeared on the Extended DVD named Scary Movie 3.5 was part of the unrated feature.