Schiller–Duval body

Schiller–Duval body is a cellular structure seen by microscope in endodermal sinus tumors (yolk sac tumors) which are the most common testicular cancer in children.

Schiller-Duval bodies are present in approximately 50% of these tumors, and if found are pathognomonic.

[1] They are named for Mathias-Marie Duval and Walter Schiller[2] who described them in the late nineteenth century.

[4] They have a mesodermal core with a central capillary, all lined by flattened layers of both visceral and parietal cells.

Immunofluorescent stain may show eosinophilic hyalin-like globules both inside and outside the cytoplasm that contain AFP and alpha 1-antitrypsin.