Schleitheim is a municipality in the canton of Schaffhausen in Switzerland, located directly on the border with Germany.

Of the rest of the land, 6.2% is settled (buildings or roads) and the remainder (0.3%) is non-productive (rivers or lakes).

This name stems from Old High German sleit (English: 'gently sloping, inclined') and Old High German heim (English: 'house, residence'), meaning "settlement on a gentle slope on the inclined plain.

[6] The blazon of the municipal coat of arms is Gules, an ox head sable lined white.

Of the foreign population, (as of 2008[update]), 45.3% are from Germany, 10.3% are from Italy, 2% are from Croatia, 25.6% are from Serbia, 1.5% are from Macedonia, and 15.3% are from another country.

Schleitheim has a regular Postbus service to and from Schaffhausen railway station.

The wettest month is August during which time Schleitheim receives an average of 95 mm (3.7 in) of rain or snow.

The driest month of the year is September with an average of 57 mm (2.2 in) of precipitation over 11 days.