[3] Schuyler County is part of the Kirksville, MO Micropolitan Statistical Area.

As of the census[9] of 2010, there were 4,431 people, 1,725 households, and 1,193 families residing in the county.

The racial makeup of the county was 98.44% White, 0.05% Black or African American, 0.31% Native American, 0.17% Asian, 0.02% Pacific Islander, 0.17% from other races, and 0.84% from two or more races.

28.20% of all households were made up of individuals, and 15.20% had someone living alone who was 65 years of age or older.

The Democratic Party predominantly controls politics at the local level in Schuyler County.

All of Schuyler County is included in Missouri's 4th District in the Missouri House of Representatives and is represented by Craig Redmon (R-Canton).