Scio is a town in Allegany County, New York, United States.

[2] The town is in the southern half of the county and north of the village of Wellsville.

The town was first settled in 1805 by Joseph Knight, a minuteman in the American Revolution, from Oneida County.

Knights Creek, which flows into the Genesee River near Scio, is named for him.

New York State Route 19 is a major north-south highway passing through the town.