The area had a vibrant community and was home to a large Irish population, but was often associated with poor housing, poverty, violence, and sectarian divisions.

[2] After the Second World War ended in 1945, many residents were rehoused in new council houses in areas such as Croxteth, Halewood, Huyton, Kirkby, Norris Green, and Stockbridge Village, leaving Scotland Road in a state of steady decline.

[4] There once were over 200 pubs in the Scotland Road area, but as of 2022[update] only The Throstles Nest, which opened in 1804, remains; it is next to St Anthony's Church.

At its southern end, Scotland Road becomes Byrom Street, the location of the largest campus of Liverpool John Moores University.

For example, on board the RMS Titanic, a broad, lower-deck working corridor on E Deck, which ran the length of the ship, was referred to by crew as "Scotland Road" (and by officers as "Park Lane").