The Scott County portion of Scott City (the majority) is part of the Sikeston Micropolitan Statistical Area, while the Cape Girardeau County portion is part of the Cape Girardeau–Jackson, MO-IL Metropolitan Statistical Area.

[5][6] The town of Fornfelt was previously known as Edna, but this name was changed as it was too similar to Edina, Missouri.

[8] In December 1848, a cholera epidemic was brought to New Orleans by emigrant ships.

Within a few weeks, it was carried to all the principal cities on the Ohio and Mississippi Rivers.

Six of the victims were Irish monks headed to a monastery near Dubuque, Iowa.

These monks were buried a few hundred yards northwest of the Thebes-Scott City railroad bridge.

[10] At the 2010 census there were 4,565 people, 1,794 households, and 1,245 families living in the city.

At the 2000 census there were 4,591 people, 1,801 households, and 1,287 families living in the city.

[15] The portion of Scott City in Cape Girardeau County is in the Cape Girardeau 63 School District,[17] which operates Central High School.