Clayton made his ATP main draw debut at the 2017 Aegon International Eastbourne on grass courts where he received a wildcard entry into the doubles draw alongside regular partner and compatriot Jonny O'Mara.

Clayton made his Grand Slam debut at the 2017 Wimbledon Championships after receiving a wildcard into the doubles main draw with Jonny O'Mara.

They would go on to lose in the second round to first seeds and eventual semi-finalists John Peers and Henri Kontinen in straight sets 3–6, 4–6, 4–6.

A similar story line would unfold the following year when again Clayton received a wild card entry into the doubles draw of the 2018 Wimbledon Championships this time partnering Liam Broady.

For a third consecutive year, Clayton received a wild card entry into the doubles draw of the 2019 Wimbledon Championships playing again with Liam Broady, but this year they would be ousted in the first round by Leonardo Mayer and Joao Sousa 6–7(3–7), 6–4, 5–7, 3–6.