The son of actor and filmmaker Clint Eastwood, he has starred in several of his father's films, including Flags of Our Fathers (2006), Gran Torino (2008), Invictus (2009), and Trouble with the Curve (2012), as well as Texas Chainsaw (2013), Fury (2014), The Longest Ride (2015), Suicide Squad (2016), Snowden (2016), The Fate of the Furious (2017), Pacific Rim Uprising (2018), The Outpost (2020), Wrath of Man (2021) and Fast X (2023).

"I've auditioned for pretty much every one of my father's movies", he said in 2015, stating that he was rejected for the Clint Eastwood-directed American Sniper.

In April 2010, Eastwood played the lead role in Enter Nowhere,[13] had a supporting role in David Ayer's 2014 film Fury, appeared in the 2015 music video for Taylor Swift's "Wildest Dreams", and starred alongside Britt Robertson in the 2015 film adaptation of Nicholas Sparks' novel The Longest Ride.

[14] In 2016, Eastwood played Lieutenant GQ Edwards in the film Suicide Squad, an adaptation of the DC Comics series.

[12] Also that year, he starred alongside Joseph Gordon-Levitt and Shailene Woodley in the biographical drama film Snowden, directed by Oliver Stone, which was released in September.

[17][18] In August 2017, Eastwood opened up to the media about the death of his former girlfriend, Jewel Brangman, who was killed on September 7, 2014, by a faulty airbag from Takata Corporation that, after Brangman was involved in minor car accident, exploded in her face, metal shrapnel severing her carotid artery.