[4] Renfroe is married; he and his wife, Pamela, met in high school[4] and have five children: Olivia, Sylvia, Vivian, and twin sons Derek and Spencer.

[6] After college, Renfroe returned to Greeley, Colorado to work for his father's company, Foundation Builders, Inc.;[4] he eventually became Vice President and part-owner of the Weld County concrete contractor.

[13] At the Republican party district assembly in April, Renfroe narrowly edged out Hall in delegate votes, earning the top spot on the primary ballot.

[14] In the Republican primary, Renfroe positioned himself as the more conservative candidate, benefiting from attacks by groups portraying Hall as "liberal" on gun control, immigration[15] and abortion.

[17][18] In the general election, Renfroe faced Democrat Solomon Little Owl, director of Native American Student Services at the University of Northern Colorado.

[19] In the predominantly Republican district, Renfroe also criticized Little Owl for his support of Referendum C and his activism against a local American Indian school mascot.

[27][28] He also introduced legislation to reduce paperwork for small businesses,[29] to allow school districts to represent themselves at truancy hearings,[30][31] and to eliminate a state database of concealed weapons permit holders.

[33] Renfroe also opposed measures to allow members of homosexual couples to adopt each other's children,[34] and to name John Denver's "Rocky Mountain High" one of Colorado's state songs.

[44] Renfroe also sponsored a bill that was killed in committee that would have allowed citizens to sue the government over violations of the right to free exercise of religion.

[45] In April, Renfroe was one of only two senators to vote against the nomination of Celeste C de Baca to the state parole board, citing concerns about her conduct as a judge.

[49] Renfroe sponsored legislation to allow small unlicensed day-care facilities to care for children from multiple families as well as a measure to add a penalty to the state statute prohibiting government employees from working as lobbyists within six months of leaving their jobs.

On March 11, 2011, when debating a bill requiring a minimal amount of time in physical education classes, he suggested that schools are feminizing boys.