His films include the Academy Award-winning Best Picture No Country for Old Men, as well as Uncut Gems, Lady Bird, Fences, The Girl with the Dragon Tattoo, The Social Network, South Park: Bigger, Longer & Uncut, School of Rock, Zoolander, The Truman Show, Clueless, The Addams Family, and eight Wes Anderson films.

On Broadway, he has won 17 Tony Awards for shows such as The Book of Mormon, Hello, Dolly!, The Humans, A View from the Bridge, Fences and Passion.

[13] In 1980, Rudin moved to Los Angeles, taking up employment at Edgar J. Scherick Associates, where he served as producer on a variety of films including I'm Dancing as Fast as I Can (1981), the NBC miniseries Little Gloria...

Rudin's first-look deal with Paramount lasted nearly 15 years, producing pictures including The First Wives Club, The Addams Family, Clueless, Sabrina and Sleepy Hollow.

In 2017 and 2018, Rudin and studio A24 released three films about adolescence by first-time writer/directors: Greta Gerwig's Lady Bird, Bo Burnham's Eighth Grade and Jonah Hill's Mid90s.

[16] On December 9, 2014, a major illegal breach of Sony's computer systems by "Guardians of Peace" hackers using Shamoon malware led to disclosure of many gigabytes of stolen information, including internal company documents.

[17][18][19] The two had suggested they should mention films about African-Americans upon meeting the president, such as Django Unchained, 12 Years a Slave, The Butler, and Amistad which all discuss slavery in the United States or the pre-civil rights era.

[21] His first Broadway play, David Henry Hwang's Face Value in 1993, was produced alongside Stuart Ostrow and Jujamcyn Theaters, and it closed after eight preview performances.

The following year, he co-produced Kathleen Turner's Broadway comeback, Indiscretions, and Ralph Fiennes' New York stage debut in Hamlet.

In 1996, Rudin produced the revival of the Stephen Sondheim and Larry Gelbart musical A Funny Thing Happened on the Way to the Forum, for which Nathan Lane won his first Tony Award.

[24] In 2010, Rudin and Carole Shorenstein Hays produced the first Broadway revival of August Wilson's Pulitzer Prize-winning play Fences, directed by Kenny Leon and starring Denzel Washington and Viola Davis.

Fences garnered ten Tony Award nominations and three wins, including Best Revival of a Play, Best Actor for Washington, and Best Actress for Davis.

The following year, Rudin was a producer for the Broadway musical The Book of Mormon, which opened in March 2011 at the Eugene O'Neill Theatre.

[27] Since 2011, Rudin has won Tony Awards for producing Arthur Miller's Death of a Salesman (directed by Mike Nichols and starring Philip Seymour Hoffman and Andrew Garfield), Lorraine Hansberry's A Raisin in the Sun (starring Denzel Washington), David Hare's Skylight (directed by Stephen Daldry and starring Carey Mulligan and Bill Nighy), Stephen Karam's The Humans, Ivo van Hove's staging of Arthur Miller's A View From The Bridge, and the record-breaking revival of Hello, Dolly!

Other notable productions include Larry David's Fish in the Dark, a hit comedy with over $13.5 million in advance sales at the box office, a record at the time.

In a public dispute, The Hollywood Reporter critic David Rooney, who had a conflict on the date of the opening, balked at the change, adding, "You know nobody works at that pace anymore, right?"

[33] Rudin produced the first Broadway production of Harper Lee's To Kill a Mockingbird, newly adapted for the stage by Aaron Sorkin, directed by Bartlett Sher, and starring Jeff Daniels.

He is in denial about his neighbors and his friends and the world around him, that it is as racist as it is, that a Maycomb County jury could possibly put Tom Robinson in jail when it's so obvious what happened here.

[46] On April 17, 2021, the Actors' Equity Association called on Rudin to release employees from any ongoing nondisclosure agreements and for actions from employers, in order to create "truly safe and harassment-free theatrical workplaces on Broadway and beyond.

[48] On April 17, Rudin released a statement apologizing for "the pain my behavior caused to individuals, directly and indirectly" and said he would "step back" from active work on his Broadway productions.

[50] In a September 2021 interview with Vanity Fair, Aaron Sorkin was asked about Rudin being fired from To Kill a Mockingbird, after an 18-month hiatus due to the COVID-19 pandemic, and said, "I think Scott got what he deserves.

[54] Rudin is married to John Barlow, who previously owned the Broadway communications firm Barlow-Hartman Public Relations.