His other film work includes Duets, Dark Blue, XXX: State of the Union, The Strangers, Barney's Version, The Vow, and Crimes of the Future.

After appearing in several small TV roles, Speedman decided to go to New York City to study for a short time at the Neighborhood Playhouse before dropping out and returning home to Toronto.

Portraying brooding college student Ben Covington opposite overnight star Keri Russell as Felicity, Speedman received much acclaim on the popular series.

In 2002, he was cast in his first major starring role in a feature, portraying an inexperienced LAPD detective caught in a web of corruption, opposite Kurt Russell, in the police drama Dark Blue.

[8] Next, Speedman portrayed the husband of a terminally ill woman opposite fellow Canadian and high-school alumna Sarah Polley in the independent drama My Life Without Me.

Speedman also starred with Liv Tyler in the 2008 horror–thriller The Strangers, and alongside Rachel Blanchard in the mystery drama Adoration, directed by Atom Egoyan.

[15] Speedman also starred in the independent Western The Last Rites of Ransom Pride alongside Lizzy Caplan and Dwight Yoakam.

Speedman last starred as XO Sam Kendal in the ABC military drama series Last Resort, which premiered on September 27, 2012.

[17] In June 2013, Speedman was selected to star in Ryan Murphy's HBO production called Open alongside Wes Bentley.