Lyrically, the song is inspired by the real-life story of the band's high school friend Sheridon, whose middle name was Scotty, and is written from the perspective of the person with whom she is having the affair.

In 2018, the song received widespread attention in Australia after featuring in the hijacking of the official website of Scott Morrison, the country's Prime Minister at the time.

[1] In the film EuroTrip, Scotty (Scott Mechlowicz) is dumped by his girlfriend Fiona (Kristin Kreuk) for a band's lead singer (Matt Damon).

In 2006 "Scotty Doesn't Know" hit the Billboard Hot 100, making Lustra among the first unsigned bands, other than Lisa Loeb, to appear on a record chart.

[3] On October 18, 2018, the Prime Minister of Australia, Scott Morrison, had his personal website taken over as a prank after his ownership of it was apparently allowed to lapse.