However, the film went through a creative retooling after the departure of stars Melissa Barrera and Jenna Ortega in late 2023, with Landon also exiting the project.
Matthew Lillard and Scott Foley, who respectively portrayed Stu Macher and Roman Bridger in Scream (1996) and Scream 3 (2000), have been cast in the film in undisclosed roles, along with Anna Camp, Mark Consuelos, Ethan Embry, Asa Germann, Mckenna Grace, Celeste O'Connor, and Sam Rechner.
[9][10] The following day, Deadline Hollywood reported that Jenna Ortega would not reprise the role of Tara Carpenter due to scheduling conflicts with the second season of the television series Wednesday.
[11] It was then reported that the film would go through a creative retooling, with the intention of bringing back other actors from the franchise, like Campbell, along with Patrick Dempsey, who portrayed Mark Kincaid in Scream 3 (2000).
[4] In December, Celeste O'Connor, Asa Germann, Mckenna Grace, Sam Rechner, and Anna Camp joined the cast in undisclosed roles.
[29] Principal photography began under the working title Scar Tissue in Atlanta, Georgia, on January 7, 2025,[30] and was expected to continue until March 12.