Sežana (pronounced [sɛˈʒaːna] ⓘ; Italian: Sesana) is a town in the Slovenian Littoral region of Slovenia, near the border with Italy.

Sežana is located on the Karst Plateau, 17 kilometres (11 miles) from Trieste, Italy, and 80 km (50 mi) from Ljubljana, the capital city of Slovenia.

The presumed suffix -ana would indicate a Romance origin, making possible a derivation from the Latin personal name Sessius.

During the Fascist period, the population was subjected to a violent Italianization policy, and many locals joined the militant anti-fascist organization TIGR.

During World War II, especially after 1943, the area became a battlefield between the Partisan resistance and the Fascist and Nazi German forces.