[13] Throughout training camp, he competed for a role at starting cornerback against Vernon Hargreaves, Ryan Smith, and Jamel Dean.

[15] On September 8, 2019, he made his professional regular season debut, but appeared mainly on special teams during a 17–31 loss to the San Francisco 49ers.

On October 6, 2019, Murphy-Bunting had four combined tackles (three solo) and made his first career interception off a throw by Teddy Bridgewater that was intended for running back Alvin Kamara as the Buccaneers lost 31–24 at the New Orleans Saints.

In Weeks 9 and 10, Murphy-Bunting started at outside cornerback in place of Carlton Davis who injured his hip during pregame warmups prior to kickoff.

[21] He finished his rookie season in 2019 with a total 44 combined tackles (37 solo), eight pass deflections, three interceptions, one touchdown, a sack, and one forced fumble while appearing in all 16 games with ten starts.

[27] The Tampa Bay Buccaneers finished the 2020 NFL season second in the NFC South with an 11–5 record and earned a Wildcard berth.

On January 9, 2021, Murphy-Bunting started in his first career playoff appearance and had two combined tackles (one solo) and intercepted a pass by Taylor Heinicke intended for wide receiver Terry McLaurin as the Buccaneers defeated the Washington Football Team 31–23 in the Wild Card Round.

[33] Defensive coordinator Todd Bowles retained Murphy-Bunting and Carlton Davis as the starting cornerback duo with Jamel Dean returned at nickelback.

After a closely contested battle, Murphy-Bunting lost his role and was demoted to backup behind starters Jamel Dean and Carlton Davis.

He finished his last season with the Tampa Bay Buccaneers with 31 total tackles (19 solo), two interceptions, seven passes defensed, and one forced fumble in 13 games and five starts.

[42] On September 10, 2023, Murphy-Bunting started in the Titans' season-opener and recorded six combined tackles (four solo) and forced a fumble during a 15–16 loss at the New Orleans Saints.

The following week, he made three combined tackles (one solo) and set a career-high with three pass deflections as the Titans defeated the Los Angeles Chargers 26–24.

On January 7, 2024, he collected a season-high eight combined tackles (seven solo) and intercepted a pass thrown by Trevor Lawrence to Zay Jones during a 28–20 victory against the Jacksonville Jaguars.

In his lone season with the Tennessee Titans, Murphy-Bunting recorded a total of 57 combined tackles (42 solo), eight pass deflections, and two interceptions in 14 games and 14 starts.

[45] Head coach Jonathan Gannon listed Murphy-Bunting and Garrett Wilson as the starting cornerbacks to begin the season.