José Sebastián Brusco (born October 8, 1974) is a formed Argentine football defender.
In 1996, he joined Racing Club de Avellaneda In 1999, he had a short spell with Toros Neza in Mexico before returning to Argentina to play for Godoy Cruz and then Instituto de Córdoba in the 2nd division.
In 2005 Brusco joined Bolivian side Blooming and won the Apertura tournament that same year.
After a couple of years with San Martín, Brusco changed colors by joining Independiente Rivadavia.
This biographical article related to association football in Argentina, about a defender born in the 1970s, is a stub.