[1] Belalcázar, also written as Benalcázar, is known as the founder of important early colonial cities in the northwestern part of South America; Quito in 1534 and Cali, Pasto and Popayán in 1537.

[3]: 226 Moving northward into present day Colombia in search of El Dorado in 1535, he entered the Cauca River Valley, founding the southwestern Colombian cities of Santiago de Cali in 1536, and Pasto and Popayán (next in importance after Quito) in 1537.

[4] Crossing overland to the Magdalena River Valley, he entered the highlands of central Colombia, which had also been reached by Gonzalo Jiménez de Quesada and Nikolaus Federmann, a German, in 1539.

As so often happened among the conquistadors, land squabbles developed again, this time between Belalcázar and Pascual de Andagoya (1495–1548), who also claimed the governorship of Popayán.

A victim of his own ambition, he died in 1551 before he could begin the voyage back to Spain to appeal the decision, in Cartagena, Colombia.