[1] Weigle studied at the Hochschule für Musik "Hanns Eisler" in horn, piano and conducting.
[2] In 2003, Weigle was named "Conductor of the Year" by the German magazine Opernwelt,[2][3] and subsequently won this award in 2005 and 2006.
[3] He conducted Wagner's Der Ring des Nibelungen, staged by Vera Nemirova, with two complete cycles in 2012.
With Oper Frankfurt, Weigle has made commercial recordings of opera for the OEHMS Classics label.
[13][14] Outside of Europe, Weigle became principal conductor of the Yomiuri Nippon Symphony Orchestra on 1 April 2019, with an initial contract of three years.