Secemin has a long and rich history, which dates back to a defensive gord, established in the 13th century among swamps and forests, in the proximity to the medieval merchant routes.

Earliest documented mention of Secemin comes from the year 1291, when Duke of Kraków and Sandomierz, Bolesław V the Chaste met here with monks from Henrykow.

Following the order of King Jagiello, Secemin became property of knight Piotr Szafraniec (Starykon coat of arms), who had distinguished himself in the Battle of Grunwald.

Szafraniec funded a stone church, and in the late Middle Ages, Secemin emerged as a local center of artisans, with butchers, shoemakers, potters, clothmakers, two watermills and a bath.

Apart from the prayer house, local Calvinists opened here a renowned school, which was supported, among others, by Mikołaj Rej, who lived in the nearby Nagłowice.

In 1862, the town almost completely burned in a great fire, and after the January Uprising, Russian government reduced Secemin to the status of a village.

On October 27, 1944, a large battle took place near Secemin, in which units of the Home Army and the Bataliony Chlopskie fought the Wehrmacht.