A. Joseph Armstrong described Sechler Run in Danville as "on the whole uninviting" in his book Trout Unlimited's Guide to Pennsylvania Limestone Streams.

It flows west and slightly south and leaves Cooper Township after a short distance.

[11] The headwaters and lower reaches of the stream are considered by the Pennsylvania Department of Environmental Protection to be impaired.

[14] Sechler Run is located between the tracks of the Delaware, Lackawanna and Western Railroad and the former Pennsylvania Canal.

[6] Historically, the Danville Stove and Manufacturing Company was located near Sechler Run.

The Hanover Brewing Company was located in the Blizzards Run sub-watershed, east of Danville.

[15] The waters of Sechler Run are sometimes diverted to a pumping station and then sent into Mahoning Creek.

[17] Sechler Run has a relatively high level of plant and animal biodiversity, especially considering that it is in an urban area.

[3] Numerous chubs inhabit holding water in the upper reaches of Sechler Run, as do smaller numbers of smallmouths.

These species are broad-winged hawk, northern flicker, red-winged blackbird, American goldfinch, eastern phoebe, song sparrow, gray catbird, and house wren.

[18] Elodea plants inhabit the lower reaches of Sechler Run in Danville.

There are five species of shrubs on the stream: Japanese barberry, witch-hazel, staghorn sumac, multiflora rose, and common blackberry.