Seco is an unincorporated community in Letcher County, Kentucky, United States.

Located in the eastern part of the state, it lies about 6 miles (9 km) E of Whitesburg.

The area was inhabited in the late 19th century, but did not receive a post office until 1915: the name derives from the South East Coal Company, which owned the land.

Tom Gish, longtime publisher of The Mountain Eagle weekly newspaper in nearby Whitesburg, was born in Seco.

This Letcher County, Kentucky state location article is a stub.