The Second Amir Sjarifuddin Cabinet (Indonesian: Kabinet Amir Sjarifuddin II) was Indonesia's sixth cabinet and was the result of a reshuffle to allow for the entry of the Masyumi Party, which gained five posts.

The cabinet lasted only two months and eleven days, from 11 November 1947 to 29 January 1948, after Masyumi withdrew its ministers in protest at the Renville Agreement the government signed with the Dutch.

Following the 11 November reshuffle, the composition of the new cabinet was announced in a meeting of the Working Committee of the Central Indonesian National Committee, which at the time served as the legislature.

[1] Realizing the government was about to sign the Renville Agreement with the Dutch, Masjumi withdrew from the cabinet in protest on 16 January 1948.

After the agreement was signed the following day, the PNI also withdrew its support for Prime Minister Amir Sjarifuddin, who resigned on 23 January.