Although the Mechanicsburg Methodist Episcopal Church's membership was small in the earliest years, it grew rapidly as a result of numerous revival meetings, which saw many people converted to Christianity under the preaching of men such as pioneer bishop Francis Asbury.

[3]: 441  Accordingly, the congregation sold the old brick edifice to the Second Baptist Church for $2,850,[3]: 481  which continued to improve the structure; in 1917, a local author stated that "It is nicely decorated on the interior and is fitted with electric lights.

It was part of a multiple property submission of approximately twenty buildings,[1] scattered throughout the village in such a low concentration that a historic district designation was not practical.

Like all four of the others, the Second Baptist Church qualified for inclusion on the Register because of its historically significant architecture, and it also was deemed important because of the place that it had played in Ohio's history.

[6] The early twenty-first century also saw restoration work performed on the building by the Champaign County Preservation Alliance, which by that point owned the property.