Kostas Karamanlis served as a Prime Minister of Greece for two consecutive terms.

During his incumbency, the period 2004-2009, he formed two cabinets.

The second Kostas Karamanlis cabinet was formed after the 2007 elections and was succeeded by the George Papandreou Cabinet.

On September 18, 2007, after the re-election of his government, Prime Minister Kostas Karamanlis announced his second cabinet, the members of which assumed office on 19 September 2007.

As part of a reorganisation of the ministries, the incoming government announced: On 7 January 2009, Karamanlis announced another major cabinet reshuffle.