The Second Callahan Block is an historic commercial building at 282 Lisbon Street in downtown Lewiston, Maine.

Built in 1909 to a design by Coombs & Gibbs, it was part of a major development by brothers Timothy and Eugene Callahan.

It is a four-story masonry structure, with a facade of yellow brick topped by a gabled cornice with projecting bracketed pediment.

The ground floor originally had two storefronts flanking the building entrance, with fluted pilasters articulating the sections.

[2] The building was commissioned by Timothy F. and Eugene A. Callahan, dealers in men's accessories.