The Second Cabinet of Lee Hsien Loong of the Government of Singapore was sworn into office on 30 May 2006, following the 2006 general election for the 11th Parliament.

As was the case previously, the Cabinet was made up exclusively of Members of Parliament from the governing People's Action Party (PAP).

In the only change at the ministerial level, Raymond Lim was promoted to be the Minister for Transport replacing Yeo Cheow Tong.

Five new faces were sworn into political office, namely Lui Tuck Yew, Lee Yi Shyan, Grace Fu, Teo Ser Luck and Masagos Zulkifli.

Professor S. Jayakumar relinquished his post of Deputy Prime Minister, and was replaced by Teo Chee Hean.