The Liberal–National coalition ministry was formed on 21 December 2021 from a reshuffle, the first time since Perrottet and Paul Toole were elected as Liberal Party leader and National Party leader respectively in October 2021.

On 18 December 2021, Don Harwin and Shelley Hancock announced that they opted not to be considered in the new ministry for personal reasons.

The reshuffle was announced the following day on 19 December 2021 and confirmed that Adam Marshall was also dropped from the ministry.

[4] There were nine new ministers appointed to the cabinet and three new portfolios created, which were Cities, Science, Innovation and Technology, and Homes.

[8] Eleni Petinos was sacked on 31 July 2022[a] (but was only officially removed from office on 3 August 2022) and Stuart Ayres resigned four days later.