Second Men's Regional League (Serbian Cyrillic: Друга мушка регионална лига, romanized: Druga muška regionalna liga) is the men's regional basketball league in Serbia.
Founded in 2006, it is run by the Basketball Federation of Serbia (KSS).
The league, operated by the Basketball Federation of Serbia and Regional Basketball Associations, consists of six divisions, North (N), North (S), Central, East, West (Group One) and West (Group Two), which have 14 teams each.
The following are the division champions of the Second Regional League: The following is the list of clubs for the 2021–22 season.
The North (South) division is composed of 11 clubs.