It is based in Midtown Manhattan, New York City, and is affiliated with the League of Resident Theatres.

[6] The first Second Stage production at the Hayes Theater was Lobby Hero in early 2018, after renovations and upgrades.

[9][10] Founding artistic director and president Carole Rothman announced that September 2023 that she would resign from her position as Second Stage’s artistic director at the end of the 2023–2024 season.

[11][12] In February 2024, Second Stage named Bennett Leak their interim artistic director for the 2024-25 season.

Also in February 2024, Second Stage decided to let go of the Tony Kiser Theater, its off-Broadway space, at the end 2024, due to high rent and unfavorable lease terms.